Channel 112834-kir

General data

• ICG id: 150
• ModelDB id: 112834
• Reference: Wolf JA, Moyer JT, Lazarewicz MT, Contreras D, Benoit-Marand M, O'Donnell P, Finkel LH (2005): NMDA/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron.

Metadata classes

• Animal Model: rat
• Brain Area: basal ganglia, nucleus accumbens (NAcc)
• Neuron Region: soma, dendrites
• Neuron Type: medium spiny projection (MSP) neuron
• Runtime Q: Q2
• Subtype: inward rectifier (IR, IR2, IRK)

Metadata generic

• Age: 48-59 days
• Authors: J Moyer.
• Comments: Kir potassium current for nucleus accumbens (irk1 = kir 2.1 mermelstein), written by j moyer 2004, cites the following: mermelstein et al (1998), uchimura et al (1989), kubo & murata (2001), and hayashi & fishman (1988). No apparent modeldb ancestors. Animal model is from experiments in paper. Channel data comes mostly from churchill & macvicar 1998, on adult rat accumbal cells. Activation kinetics fit to mouse data from kubo and murata 2001.
• Runtime: 7.568
• Temperature: No apparent temperature dependence. Experiments done at 33-35 deg C, simulations at 35 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp