Channel 144490-kaprox

General data

• ICG id: 1425
• ModelDB id: 144490
• Reference: Sterratt DC, Groen MR, Meredith RM, van Ooyen A (2012): Spine calcium transients induced by synaptically-evoked action potentials can predict synapse location and establish synaptic democracy.

Metadata classes

• Animal Model: Wistar, rat
• Brain Area: hippocampus, CA1
• Neuron Region: soma, dendrites, apical dendrites, basal dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q3
• Subtype: A

Metadata generic

• Age: P28-42
• Authors: M Migliore
• Comments: K-a channel from poirazi et al. (2003), originally from migliore et al. (1999), used only in locations >100 microns from the soma. Taken from poirazi et al. (2003), model no. 20212, with some changes in implementation but no apparent modification to kinetics or parameters. [this file is from the main directory of model] modeling study, identical to ancestor model save the addition of schaffer collateral spines to dendrites. Experimental results from calcium imaging. Animal model reflects the calcium imaging data. The model was also implemented in two new ca1 pn morphologies but their origin is not clear.
• Runtime: 7.761
• Temperature: Model has temperature dependence, with q10 set to 5.0 and original kinetics at 24 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp