Channel 143719-kaprox

General data

• ICG id: 1258
• ModelDB id: 143719
• Reference: Bianchi D, Marasco A, Limongiello A, Marchetti C, Marie H, Tirozzi B, Migliore M (2012): On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons.

Metadata classes

• Animal Model: Sprague-Dawley, rat
• Brain Area: hippocampus, CA1
• Neuron Region: single compartment
• Neuron Type: pyramidal cell
• Runtime Q: Q4 (slow)
• Subtype: A

Metadata generic

• Age: P19-24
• Authors: M Migliore
• Comments: Ka channel originally from migliore et al. (1999). The neuron model was formed by merging poirazi et al. (2003b) (20212) and shah et al. (2008) (112546). According to the paper appendix, the ka current is as described in shah et al. (2008), but the mod file resembles the poirazi et al. (2003b) more. Both models are listed as ancestors here. Experimental and modeling results in this paper. The animal model info here is from the experimental results, morphology was reduced to a single compartment.
• Runtime: 8.472
• Temperature: Model has temperature dependence, with default temperature of 24 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp