Channel 112546-km

General data

• ICG id: 116
• ModelDB id: 112546
• Reference: Shah MM, Migliore M, Valencia I, Cooper EC, Brown DA (2008): Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons.

Metadata classes

• Animal Model: rat
• Brain Area: hippocampus, CA1
• Neuron Region: soma, dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q2
• Subtype: m

Metadata generic

• Age: 5-6 weeks old
• Authors: M Migliore
• Comments: Ca1 km channel from mala shah, m. Migliore june 2006. Morphology used in this model is from migliore et al. (2005), but no references are given for channel kinetics. We cite hemond et al. (2008), model no. 101629, because most of the mod files are the same. This channel has the following changes: parameter a0t is set to 0.009 from 0.003, shift parameter sh is defined and set to 24. This paper contains experimental results and modeling based on the model in migliore et al. (2005) and others. The animal model info here is from the experimental methods. The morphology used in the model was the same as in migliore et al. (2005), slightly older rats.
• Runtime: 7.656
• Temperature: Model has temperature dependence, with q10 set to 5.0 and original kinetics at 35 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp