Channel 45539-ka

General data

• ICG id: 2895
• ModelDB id: 45539
• Reference: Traub RD, Contreras D, Whittington MA (2005): Combined experimental/simulation studies of cellular and network mechanisms of epileptogenesis in vitro and in vivo.

Metadata classes

• Animal Model: rat
• Brain Area: layer 5, layer 2/3, cortex, auditory cortex, thalamocortical circuit, parietal cortex, layer 6, layer 4, barrel cortex
• Neuron Region: soma, dendrites, axon
• Neuron Type: pyramidal cell, fast rhythmic bursting (FRB), thalamocortical relay cell (TC, TCR), thalamic reticular (RE) cell, regular spiking (RS) cell, intrinsically bursting (IB) cell, fast-spiking (FS) cell, low-threshold spiking (LTS) cell, interneuron, stellate cell, spiny cell, nontufted cell, tufted cell
• Runtime Q: Q2
• Subtype: A

Metadata generic

• Age: adult
• Authors: M Lazarewicz.
• Comments: Modeling based on traub et al. (1994) and traub et al. (2003c), conductances from traub et al. 2003 and cunningham et al. 2004. Potassium type a current for rd traub, 2003, model no. 20756. Implemented by m lazarewicz, 2003. Based on data in huguenard and mccormick (1992) and mccormick and huguenard (1992), with only the faster component of inactivation was used and the activation variable m was first order. Modifications from ancestor channel: addition of variables alphah and alpham for debugging, and <= (line 64). No apparent change in kinetics. Modeling study, with many neurons in the cortex and thalamus. All neurons contain this channel except tufted ib neurons which have their own ka model. The animal model info here is from electrophysiology experiments also in this paper, both in vivo and in vitro.
• Runtime: 7.53
• Temperature: Channel model has no temperature dependence. Experiments done at 34-37 deg C, simulations likely done at physiological temperatures.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp