Channel 145672-Kv4_csi

General data

• ICG id: 2812
• ModelDB id: 145672
• Reference: Fineberg JD, Ritter DM, Covarrubias M (2012): Modeling-independent elucidation of inactivation pathways in recombinant and native A-type Kv channels.

Metadata classes

• Animal Model: Sprague-Dawley, rat
• Brain Area: hippocampus, CA1
• Neuron Region: dendrites, distal dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q4 (slow)
• Subtype: 4

Metadata generic

• Age: 5-8 weeks
• Authors: DM Ritter
• Comments: Kv4 csi (closed-state inactivation) markov model from fineberg, ritter and covarrubias (2012), based on amarillo et al. (2008) and fitted to theoretical currents generated from model in migliore et al. (1999). Used to replace the distal a-type channels. No modeldb ancestors. Animal model is from ancestor (migliore et al. 1999). Experiments in this paper were done on granule neurons (cgn) and dorsal root ganglion neurons (drg), but these were not modeled explicitly.
• Runtime: 16.762
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp